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Golden Retriever Lifetime Study PSA – For Golden Owners (1Min)

EPA-generated annual 4th max 8-h average ozone and weight annual mean PM2.5 concentrations for each dogs county of longest residence was acquired from publicly available data on the EPA website between the years of 20132019. For each county, the average 4th max 8-h average ozone over the years of residence was calculated and subsequently dichotomized based on the EPA regulatory limit of 70 ppb. The concentration of PM2.5 over the years of residence was treated as a continuous variable due to a low number of residences exceeding the EPA regulatory limit of 12 ug/m3.

Episode 4: Update On The Golden Retriever Lifetime Study

May 12, 2022

Dr. Kelly Diehl chats with Dr. Julia Labadie, Golden RetrieverLifetime Study epidemiologist, and gets an update on the latestfacts and figures as the Study reaches its tenth anniversary!

About the Podcast

The science of animal health is ever-changing, and veterinarians need cutting-edge research information to give their patients the best possible care. Each month, join Dr. Kelly Diehl, Scientific Adviser at Morris Animal Foundation, as she interviews Foundation-funded researchers and discusses the clinical implications of their work. Whether youre a practicing veterinarian, technician or student, or just an animal-loving science geek, Fresh Scoop is the podcast for you. Learn more at morrisanimalfoundation.org.

A Look At The Golden Retriever Lifetime Study Participants

Michael Lappin, DVM, veterinarian and owner of The Animal House in Buzzards Bay, Massachusetts, has been active with Golden Retriever clubs for nearly four decades. He jumped at the opportunity to participate in this study. His clinic has 17 Golden Retrievers enrolled in the study including his own dog, Isaac a total that is believed to be the highest by any single clinic in the study.

We have a lot of Golden Retrievers in our practice, Dr. Lappin says. Isaac is known as Hero #64 in the study. He is a very happy dog and healthy so far. Goldens are generally easygoing with a stable demeanor, but the biggest problem is the high rate of cancer in this breed. This study could be a real game changer.

How You Can Help: If you would like to learn more or donate to this study, contact the Morris Animal Foundation, a nonprofit group based in Denver, Colorado, at morrisanimalfoundation.org.

Each August, Dr. Lappin invites all his clients and the Golden Retrievers to a fun picnic. People bring covered dishes and share all things Golden. The event is hosted on a spacious property with a pond belonging to Heather Donnelly. Her home includes five Goldens, including Shannon, a 5-year-old in the MAF study.

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Lifetime Study On Golden Retrievers Searching For Participants

Visit Dr. Ernie Wardat www.DrErnieWard.com or on .

America is in love with Golden retrievers. Goldens have been a mainstay on the American Kennel Clubs Top 10 most popular breeds list for years. Golden retrievers star in movies, are featured on television programs, and have become synonymous with children playing in a park. Despite their popularity, little is known about the specific health risks this genial breed faces. The Morris Animal Foundation is looking to change that with an ambitious and important new study that hopes to learn more about diseases that threaten all dogs.

Dubbed the Golden Retriever Lifetime Study, researchers are looking for 3,000 volunteer Golden retrievers to follow for the next 10 to 14 years. The primary purpose of the study is to determine why cancer kills over half of all Golden retrievers and is the leading cause of death in adult dogs, regardless of breed. Other objectives for this landmark investigation include how genetics, environment,and diet affect health risks and what role they play in the development of cancer.

If you have any questions or concerns, you should always visit or call your veterinarian they are your best resource to ensure the health and well-being of your pets.

The opinions and views expressed in this post are those of the author’s and do not necessarily represent the beliefs, policies or positions of PetHealthNetwork.com, IDEXX Laboratories, Inc. or its affiliates and partner companies.

The Canine Lifetime Health Project

Sammy, Podley and Cinda

Morris Animal Foundation, founded in 1948, is a public nonprofit organization that funds humane scientific studies to advance animal health. The Canine Lifetime Health Project was initiated by Morris Animal Foundation in 2012 as the first-of-its-kind database to register dog owners interested in participating in clinical research studies. The CLHP website registers dog owners and their dogs of all ages and breeds including mixed-breed dogs. The concept of the CLHP website as the gateway to a community of dog owners accessible for separate health studies is similar to that used for human clinical research by the Army of Women , where both women and men can register online to be eligible to participate in studies related to breast cancer. The Love/Avon Army of Women was started by the Dr. Susan Love Research Foundation in 2008 and has since registered over 375 000 people of which various subsets have participated in at least 19 studies.

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Value Of Prospective Longitudinal Studies

The GRLS is a prospective longitudinal cohort study. A cohort study is a defined group of individuals who are followed over a defined period of time . Cohort studies form a suitable model to simultaneously evaluate both multiple exposures and multiple outcomes of disease . Prospective cohort studies offer opportunity to collect data on time varying exposures and confounders. Golden Retrievers were selected as the canine population of interest for several reasons. They are a very popular breed in the USA which increases the likelihood of sufficient enrolment in a fiscally reasonable time. Following a purebred cohort of Golden Retrievers will help reduce the genetic variability that would be inherent in a mixed-breed dog population study. The Golden Retriever breed is also suspected of being at high risk for cancer development, as described below. Golden Retrievers are owned by a diverse population of humans which helps to create dispersed environmental exposures. The GRLS attempts to reduce selection bias, the selection of individuals for a study that are not representative of the larger population, by recruiting a large number of participants from all geographical regions throughout the contiguous United States, and by recruiting a diverse participant pool through broad outreach to dog owners, breeders and veterinarians.

The Following Hvgrc Members And Their Dogs Are Enrolled In This Study:

Audrey Coleman HRCH Skylights Repeat Offender SH CDX CCA CGC Pete Hero #770

Pete was enrolled in the study July of 2013 and is 9 years old.

Joe & Lorraine Cusimano Overlook Blend of Sun and Skye CGCA THDX CCA Sundance Hero #2671

Sundance was enrolled in the study January of 2015 and is 8 years old

Alyson Fuge Jacarandas Running Wild CCA Brooke Study # 094-023415 Jacarandas Dancing With The Stars TD CCA Chelsea Study # 094-0033733

Chelsea was enrolled in the study in 2013 and died at age 8. Necropsy revealed death from multiple myeloma.

Brooke was enrolled in the study in 2014 and is 8 years old.

Lynn Halpern Overlook Sutton Downpour CDY RA CGC CCA William Study # 094-030652

William was enrolled in the study in 2015 and is 8 years old.

Chris Miele Cross Creek Waltz Right In AX AXJ OF Matilda Hero # 16 Cross Creek EZ Breezy Cover Girl OA AXJ OF Flirt Hero # 1705

Matilda was enrolled in the study June 2012 and is 10 years old.

Flirt was enrolled in the study May 2014 and is 8 years old.

Jean Owen MACH 5 OTCH Morningstars Sky High IQ UDX2 OM4 OM4 Smartie Pantz Hero # 920

Smartie Pantz was enrolled in the study March 2013 and is 9 years old.

Memorials

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Cohort Profile: The Golden Retriever Lifetime Study

  • Roles Data curation, Visualization, Writing review & editing

    Affiliation Scientific Programs Department, Morris Animal Foundation, Denver, Colorado, United States of America

  • Roles Data curation, Project administration, Writing review & editing

    Affiliation Scientific Programs Department, Morris Animal Foundation, Denver, Colorado, United States of America

  • Roles Data curation, Project administration, Writing review & editing

    Affiliation Scientific Programs Department, Morris Animal Foundation, Denver, Colorado, United States of America

  • Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing review & editing

    ¶ RP and JPK are joint senior authors on this work.

    Affiliation Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, United States of America

  • Roles Funding acquisition, Supervision, Writing review & editing

    ¶ RP and JPK are joint senior authors on this work.

    Affiliation Scientific Programs Department, Morris Animal Foundation, Denver, Colorado, United States of America

Spontaneous Cancers In Dogsthe Primary Endpoint For The Golden Retriever Lifetime Study

What we’re learning from 3,000 dogs in the Golden Retriever Lifetime Study

Cancer is considered a leading cause of morbidity and mortality in pet dogs although the extent of the cancer burden on the health and longevity of dogs is not well characterized . A formal cancer registry, no longer in use, was developed 60 years ago in the San Francisco area by the National Cancer Institute but since then there has not been a significantly accurate way to estimate changes in cancer incidence in the USA . Current estimates of cancer frequency do exist from several large national databases such as the Veterinary Medical Database which represents a collection of medical record abstracts from most of the veterinary teaching hospitals associated with colleges of veterinary medicine in the USA. This dataset has been used for comparisons of canine cancer frequency by histological type, dog breed and other demographic characteristics but is inherently biased due to the population of dogs sampled at regional veterinary referral hospitals .

Several areas of current investigation related to cancer aetiology include the role of chronic inflammation, epigenetic modulation of gene expression and metagenomics . Thorough archival collections, such as those generated by the GRLS, will be required to develop appropriate hypotheses as to how these factors may be manifested in clinical syndromes such as cancer.

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Seven Years Of The Golden Retriever Lifetime Study

When Morris Animal Foundation launched its Golden Retriever Lifetime Study in 2012, the organization was taking a bold step into uncharted territory. Using the groundbreaking Framingham human heart study as a model, the Foundation design a similar study focused on canine cancer. Seven years later, the study is going strong and researchers are looking forward to the first published papers coming out later this year looking at early health outcomes.

The idea for the study was the result of a fortuitous conversation in 2008 between three key individuals: Bette Morris, long-time Foundation trustee and respected scientist Dr. Rod Page, Professor and Director of the Flint Animal Cancer Center at Colorado State University and Dr. Patty Olson, CEO and President of Morris Animal Foundation at the time.

Amber, Hero #2715

Cancer was the topic of conversation. It remains the major cause of death in older dogs and, although great strides have been made in treating cancer, the conversation turned to identifying risk factors for the disease. If we could understand what leads to a higher risk for cancer, steps could be taken to remove these risks, ultimately preventing cancer from developing.

Butters, Hero #2592

We couldnt do this work without the veterinarians, owners and dogs enrolled in the study, and without the support of individual donors and companies like Coastal Pet Products. Thanks to all who are making the Golden Retriever Lifetime Study a going success.

We Are Always Looking For Veterinarians Ready And Willing To Help When A Study Dog Needs A New Veterinarian

Because people move. Dogs move. Veterinarians move. And veterinarians retire. By enrolling with us, you can become a part of veterinary history and contribute greatly to what we know about risk factors, disease and dogs.

As a Study veterinarian, youll need to:

  • Perform routine annual exams for each enrolled dog at your practice
  • Collect blood, urine, feces, hair and nail samples at each annual exam and send them to a designated laboratory for analysis*
  • Provide care during other health events, such as illness or injury, and collect samples for evaluation and submission to the laboratory
  • Ensure Study dogs in your practice are microchipped

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The Golden Retriever Lifetime Study: 5 Years Of Progress In Veterinary Health And Biobanking

Cancer is the leading cause of death in dogs over the age of two, and Golden Retrievers are at high risk of cancer development. Morris Animal Foundation wishes to better define the incidence and risk factors for cancer in GRs enrolled in this cohort and assess the risk factors for other major medical conditions, diseases and disorders in GRs enrolled in this cohort by conducting a prospective lifetime cohort study.

The Golden Retriever Lifetime Study is a prospective cohort study of approximately 3,000 GRs under the age of 2 years at enrollment with subsequent annual health exams, laboratory tests, questionnaire responses, and sample collection for archival storage. Dogs will be followed from the time of enrollment until death.

An objective of this study is to establish extensive data and biological sample repositories for future analyses of major diseases, disorders or conditions in Golden Retrievers.

Update On Golden Retriever Lifetime Study Published

Honor Card: Golden Retriever

As the Morris Animal Foundation Golden Retriever Lifetime Study approaches its 10th anniversary, a newly published paper in the journal PLOS ONE reviews the study’s findings to date and previews research in progress.

The latest publication from the study team summarizes the current demographics of the cohort as well as reports on health parameters such as cancer diagnoses and deaths.

“The new publication provides detailed information on our cohort as of May 2021,” said Dr. Julia Labadie, former study epidemiologist, currently Senior Scientist, Statistical Genetics at Wisdom Health, and the paper’s lead author. “We hope the paper will not only update the veterinary and lay communities about the study but will stimulate more researchers to contact us for access to samples and data.”

The paper includes an update on the primary endpoints, as of May 31, 2021, that are tracking the occurrence of the four major cancers of interesthemangiosarcoma, lymphoma/leukemia, osteosarcoma, and high-grade mast cell tumors. At that time, the study had obtained 223 of the 500 desired primary endpoints, with hemangiosarcoma being the most common. The current paper also reports on some of the challenges the study is addressing, including adjudication of veterinary diagnoses.

More information:Julia Labadie et al, Cohort profile: The Golden Retriever Lifetime Study , PLOS ONE . DOI: 10.1371/journal.pone.0269425

Journal information:

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Annual Study Examination Resources

  • Dam and Sire History – This form assists with completing the dam and sire history section of the study questionnaire. For second year annual examinations your veterinarian will input this information. Starting with third-year annual examinations this information will be included on your owner questionnaire.
  • Glossary for Dam and Sire History – Refer to this glossary to help you complete the Sire and Dam Medical History.

Golden Retriever Lifetime Study Info For Puppy Buyers

Dear Golden Retriever Owner,

Congratulations on the recent addition to your family!

The Golden Retriever Club of America would like to take a moment to tell you about an opportunity for you and your puppy to make a significant impact on the health of dogs. Morris Animal Foundation is conducting the Golden Retriever Lifetime Study that is enrolling 3,000 Golden Retrievers between 6 months and 2 years of age in the largest and longest study ever conducted to advance veterinary medicine for dogs.

While a study of this magnitude has never been done before in dogs, similar studies in humans, such as the Framingham Heart Study and the Nurses Health Study, have contributed a wealth of information that is improving and extending lives every day. These observational studies have provided invaluable information about human health, and we are incredibly excited that Morris Animal Foundation chose our breed for this groundbreaking study in dogs. By gathering noninvasive samples and observational data over the lifetime of enrolled dogs, researchers hope to identify potentially modifiable risk factors for the development of cancer and other diseases that affect Goldens. It is estimated that about 60 percent of Golden Retrievers die from cancer, so this study is of special importance to our breed, but will also benefit all dogs.

Sincerely,

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Relevance To Peto’s Paradox

The development of cancer in the canine species provides several interesting observations relative to Peto’s paradox . The premise of the paradox is based upon evidence that the frequency of cancer development is independent of the quantity of cells within an organism when considered across the spectrum of all mammalian species. The canine species has the most conformational diversity of all terrestrial mammals. Within the canine species, it has been observed that large breed dogs have a greater frequency of cancer development than do small dogs . Thus, Peto’s paradox does not seemingly apply to the canine species. What might be some of the reasons that dogs appear to represent an inconsistency with this theory?

The genetic influence of size variation on dogs has been linked to haplotype differences in the insulin-like growth factor 1 gene . However, it is currently unknown if IGF1/IGF1-receptor biology also influences cancer frequency between large and small breeds, although it is tempting to speculate that cancer frequency may be linked to genetic determinants of size.

It is well known that the major types of cancers that impact the lives of dogs differ from the leading causes of cancer deaths in people , which may suggest that the process of carcinogenesis between species is significantly influenced by differing geneenvironment interactions or epigenetic modifications to such an extent that the patterns of cancer may not be comparable .

Translational Opportunities Of Golden Retriever Lifetime Study To Human Health

Morris Animal Foundation discusses lymphoma for Golden Retriever Lifetime Study participants

Naturally occurring diseases and conditions in companion animals have been recognized as valuable correlates of disorders that affect humans in both the biology of disease development and for purposes of early detection and treatment. The field of comparative medicine investigating naturally occurring disorders in pets is specifically relevant to the many diseases that have a genetic basis for disease in both animals and humans, including cancer, blindness, metabolic and behavioural disorders and some neurodegenerative disorders. The opportunity of the GRLS to provide high-quality data for translational comparative medical initiatives in several disease categories is great. In particular, the opportunity to develop a lifetime dataset of lifestyle and activity, environmental exposure and diet history combined with simultaneous annual biological sample sets will facilitate association studies between important shared health outcomes and a wide variety of potential risk factors. Such analyses might expedite the development or modification of future human health investigations. Importantly, the entire data and sample accumulation phase for the GRLS will be complete in 1014 years and will include the opportunity to expand this cohort to numerous other parallel studies including the evaluation of multi-generational issues and sibling associations. Comparable work in humans requires decades.

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